May 06, 2021 · Media: Shai Biran, Ph.D. [email protected] Tel: +1 978 254 6286 Thomas Schneckenburger, European IR & Media [email protected] Tel: +41 79 407 9952
Apr 21, 2021 · In South Africa, where a variant with a worrisome mutation – known as E484K – is spreading, clinical trials showed the AstraZeneca vaccine did not prevent mild to moderate infections there.

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Feb 20, 2021 · Like the South African variant, first detected in Ireland last month, the Brazilian strain includes a key mutation, called E484K, which may help the virus evade antibodies, part of the immune system.
Jan 20, 2021 · Those changes altered the shape of small parts of the coronavirus spike protein that binds with human cells (technically, the most worrisome change is in the S receptor binding domain, from a genetic variation called N501Y and, in the South African and Brazil variants, a combination of N501Y and E484K).

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Jan 06, 2021 · “The finding of the E484K, in an episode of SARS-CoV-2 reinfection might have major implications for public health policies, surveillance and immunization strategies,” the authors wrote.
Apr 13, 2021 · Another mutation, called E484K, could help the virus dodge a person's immune system and may affect how well coronavirus vaccines work.

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Feb 10, 2021 · Like the UK variant, it also has the N501Y mutation in the spike protein, meaning it’s more efficient at gaining access to our cells to replicate. This may help to explain its rapid spread. It also contains several other concerning mutations. Two of these, called “E484K” and “K417N”, are bad news for our immune system.
Jan 10, 2021 · The E484K mutation has independently cropped up in many different parts of the world, an indication that it offers the virus a significant advantage. “Variants that have an advantage are going to rise pretty fast in frequency, especially when numbers are coming down over all,” said Andrew Read, an evolutionary microbiologist at Penn State ...

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May 12, 2021 · moderna has become the first vaccine maker to develop a jab that targets the South African coronavirus variant.The Boston-based biotech has already
Feb 10, 2021 · Like the UK variant, it also has the N501Y mutation in the spike protein, meaning it’s more efficient at gaining access to our cells to replicate. This may help to explain its rapid spread. It also contains several other concerning mutations. Two of these, called “E484K” and “K417N”, are bad news for our immune system.

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Second, B.1.617 has a similar mutation (called E484Q) as the one present in the variants first detected in South Africa and Brazil (that mutation is called E484K). So in a nutshell, B.1.617 has ...
Mar 04, 2021 · The E484K mutation is also located in the spike of the virus and could reduce antibody response. One study from Seattle showed that it caused the neutralizing effects of antibodies to decrease by ...

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Feb 02, 2021 · Still, seeing the E484K mutation pop up in the U.K. variant doesn't necessarily mean that this variant will become both more contagious and resistant to vaccines, according to The New York Times ...
Mar 28, 2021 · Also of concern is the B1.351 - or South African - variant, which contains the E484k mutation, which can make it less susceptible to antibodies produced by a vaccine or by having previously caught ...

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Feb 03, 2021 · Adding the E484K mutation appeared to raise the bar for the level of antibodies needed to prevent the lab-made virus from infecting cells, when compared to B.1.1.7 mutations on their own.
Jan 04, 2021 · “The E484K mutation has been shown to reduce antibody recognition,” said Professor Francois Balloux from University College London. “As such, it helps the virus bypass immune protection ...

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First sequenced in September 2020, the UK variant of coronavirus emerged in southeast England, and is commonly known as B.1.1.7. It is around 1.5 times more transmissible than other covid variants ...
May 10, 2021 · Boris Johnson announces further lifting of lockdown rules Speaking from Downing Street today, Prime Minister Boris Johnson confirmed lockdown restrictions will ease yet further on May 17 as planned, meaning indoor socialisation can take place, with social contact permitted. The Government is closely monitoring Covid data across the UK, with specific tests in place to […]

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May 09, 2021 · That is the basis of dubbing it ‘double mutant’. This does not necessarily mean that it contains just two mutations; it has rather more than a dozen. One mutation, E484Q, is similar to the E484K mutation in the Brazilian variant, the South African variant and some strains of the UK variant.
Apr 22, 2021 · Genome sequencing revealed multiple mutations in both viral samples, including the E484K variant in one individual, first identified in South Africa and Brazil, and the S477N variant in the other ...
Feb 09, 2021 · This has both N501Y and E484K, meaning it can spread fast and may get past the immune system. 170 cases have been confirmed in the UK. Brazil variant 1. Known as P1, this has both N501Y and E484K ...
Jan 25, 2021 · Moderna and Pfizer vaccines may be effective against British COVID-19 strain, but a new vaccine might be needed for a South African strain.
Mar 05, 2021 · PHE said this latest identified strain, also known as B.1.1.318, contains the E484K mutation which has been found in the South Africa and Brazil variants in the UK, which are both VUIs.

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