Apr 21, 2021 · In South Africa, where a variant with a worrisome mutation – known as E484K – is spreading, clinical trials showed the AstraZeneca vaccine did not prevent mild to moderate infections there.
Jan 20, 2021 · Those changes altered the shape of small parts of the coronavirus spike protein that binds with human cells (technically, the most worrisome change is in the S receptor binding domain, from a genetic variation called N501Y and, in the South African and Brazil variants, a combination of N501Y and E484K).
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Apr 13, 2021 · Another mutation, called E484K, could help the virus dodge a person's immune system and may affect how well coronavirus vaccines work.
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Jan 10, 2021 · The E484K mutation has independently cropped up in many different parts of the world, an indication that it offers the virus a significant advantage. “Variants that have an advantage are going to rise pretty fast in frequency, especially when numbers are coming down over all,” said Andrew Read, an evolutionary microbiologist at Penn State ...
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Feb 10, 2021 · Like the UK variant, it also has the N501Y mutation in the spike protein, meaning it’s more efficient at gaining access to our cells to replicate. This may help to explain its rapid spread. It also contains several other concerning mutations. Two of these, called “E484K” and “K417N”, are bad news for our immune system.
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Mar 04, 2021 · The E484K mutation is also located in the spike of the virus and could reduce antibody response. One study from Seattle showed that it caused the neutralizing effects of antibodies to decrease by ...
Mar 28, 2021 · Also of concern is the B1.351 - or South African - variant, which contains the E484k mutation, which can make it less susceptible to antibodies produced by a vaccine or by having previously caught ...
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Jan 04, 2021 · “The E484K mutation has been shown to reduce antibody recognition,” said Professor Francois Balloux from University College London. “As such, it helps the virus bypass immune protection ...
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May 10, 2021 · Boris Johnson announces further lifting of lockdown rules Speaking from Downing Street today, Prime Minister Boris Johnson confirmed lockdown restrictions will ease yet further on May 17 as planned, meaning indoor socialisation can take place, with social contact permitted. The Government is closely monitoring Covid data across the UK, with specific tests in place to […]
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May 09, 2021 · That is the basis of dubbing it ‘double mutant’. This does not necessarily mean that it contains just two mutations; it has rather more than a dozen. One mutation, E484Q, is similar to the E484K mutation in the Brazilian variant, the South African variant and some strains of the UK variant.
Apr 22, 2021 · Genome sequencing revealed multiple mutations in both viral samples, including the E484K variant in one individual, first identified in South Africa and Brazil, and the S477N variant in the other ...
Feb 09, 2021 · This has both N501Y and E484K, meaning it can spread fast and may get past the immune system. 170 cases have been confirmed in the UK. Brazil variant 1. Known as P1, this has both N501Y and E484K ...
Jan 25, 2021 · Moderna and Pfizer vaccines may be effective against British COVID-19 strain, but a new vaccine might be needed for a South African strain.
Mar 05, 2021 · PHE said this latest identified strain, also known as B.1.1.318, contains the E484K mutation which has been found in the South Africa and Brazil variants in the UK, which are both VUIs.